Endothelial Unc5B controls blood-brain barrier integrity
| Autor: | Kevin Boyé, Luiz Henrique Geraldo, Jessica Furtado, Laurence Pibouin-Fragner, Mathilde Poulet, Doyeun Kim, Bryce Nelson, Yunling Xu, Laurent Jacob, Nawal Maissa, Dritan Agalliu, Lena Claesson-Welsh, Susan L. Ackerman, Anne Eichmann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 79457975 |
| DOI: | 10.1038/s41467-022-28785-9 |
| Popis: | The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink