| Autor: |
Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1741-7015 |
| DOI: |
10.1186/s12916-023-03223-9 |
| Popis: |
Abstract Background Adverse pregnancy outcomes (APO) may unmask or exacerbate a woman’s underlying risk for coronary heart disease (CHD). We estimated associations of maternal and paternal genetically predicted liability for CHD with lifelong risk of APOs. We hypothesized that associations would be found for women, but not their male partners (negative controls). Methods We studied up to 83,969 women (and up to 55,568 male partners) from the Norwegian Mother, Father and Child Cohort Study or the Trøndelag Health Study with genotyping data and lifetime history of any APO in their pregnancies (1967–2019) in the Medical Birth Registry of Norway (miscarriage, stillbirth, hypertensive disorders of pregnancy, gestational diabetes, small for gestational age, large for gestational age, and spontaneous preterm birth). Maternal and paternal genetic risk scores (GRS) for CHD were generated using 148 gene variants (p-value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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