Skin Manifestations in Patients with Adult-onset Immunodeficiency due to Anti-interferon-gamma Autoantibody: A Relationship with Systemic Infections

Autor:	Kamonwan Jutivorakool, Prattana Sittiwattanawong, Kornphaka Kantikosum, Cameron P. Hurst, Chanat Kumtornrut, Pravit Asawanonda, Jettanong Klaewsongkram, Pawinee Rerknimitr
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	skinsigns neutrophilicdermatoses Sweetsyndrome IFN-gamma autoantibody acquiredimmunodeficiency Dermatology RL1-803
Zdroj:	Acta Dermato-Venereologica, Vol 98, Iss 8, Pp 742-747 (2018)
Druh dokumentu:	article
ISSN:	0001-5555 1651-2057 00015555
DOI:	10.2340/00015555-2959
Popis:	Adult-onset immunodeficiency due to anti-interferon-γ autoantibody is an emerging acquired immunodeficiency with frequent skin manifestations. A retrospective chart review was conducted and identified 41 patients with the syndrome. Skin involvement was detected in 33 (80%) patients, 15 (45%) with infective skin diseases and 27 (82%) with reactive skin disorders. Reactive lesions were mostly neutrophilic dermatoses, e.g. Sweet syndrome. Of note, the presence of neutrophilic dermatoses was highly associated with infections of other sites. An adjusted odds ratio for the existence of infections in patients with neutrophilic dermatoses was 14.79 (95% CI: 5.13, 42.70; p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/792f0fe917f7496e9c63716f655bcfb3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF