| Autor: |
Julian A. Luetkens, Anne C. Wolpers, Thomas Beiert, Daniel Kuetting, Darius Dabir, Rami Homsi, Hendrik Meendermann, Natalie Abou Dayé, Vincent Knappe, Morten Karsdal, Signe H. Nielsen, Federica Genovese, Florian Stöckigt, Markus Linhart, Daniel Thomas, Georg Nickenig, Hans H. Schild, Jan W. Schrickel, René P. Andrié |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-018-31916-2 |
| Popis: |
Abstract To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation times were assessed using CMR. Plasma levels of relaxin, myeloperoxidase and serum levels of matrix metalloproteinase (MMP)-mediated cardiac specific titin fragmentation and MMP-mediated type IV collagen degradation were obtained. Poor outcome was defined by the recurrence of AF during 1-year follow-up. 61 patients were included in final analysis. Twenty (32.8%) patients had recurrence of AF. Patients with a recurrence of AF had a higher percentage of LA LGE (26.7 ± 12.5% vs. 17.0 ± 7.7%; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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