| Autor: |
Ya Pei, John S. Parks, Hye Won Kang |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 85, Iss , Pp 104614- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2021.104614 |
| Popis: |
Inflammation in brown adipose tissue (BAT) causes BAT to lose its ability to regulate energy metabolism, which exacerbates obesity development. This study investigated the anti-inflammatory and antioxidant effects of quercetin on BAT in high-fat diet (HFD)-induced obese mice. Quercetin reduced proinflammatory and macrophage genes and increased antioxidant genes in the BAT of HFD-fed mice and in TNFα-induced brown adipocytes. In addition to increasing silent mating type information regulation 2 homolog 1 (SIRT1) levels, quercetin suppressed nuclear translocation and increased deacetylation of the nuclear factor kappa B (NFκB) subunit p65. The effects of quercetin on SIRT1 and NFκB p65 deacetylation disappeared in SIRT1-knockdown brown adipocytes. MicroRNAs that negatively regulate SIRT1 were downregulated in the BAT of HFDQ-fed mice. Taken together, these results suggest that quercetin improves obesity-induced inflammation in BAT by suppressing the NFκB pathway through activation of SIRT1. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect