Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography

Autor: Yang Deng, Qi-Wen Zhong, Ai-Qi Zhang, Xiao-Juan Cai, Ming-Zhi Lu, Shao-Chong Zhang, Li-Shi Su, Hui Chen, Ying Lin, Li-Mei Sun, Guan-Di Chen, Li-Ting Zhong, Chen-Jin Jin, Wei Chi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: International Journal of Ophthalmology, Vol 12, Iss 5, Pp 802-808 (2019)
Druh dokumentu: article
ISSN: 2222-3959
2227-4898
DOI: 10.18240/ijo.2019.05.16
Popis: AIM: To investigate microvascular changes in eyes with central retinal vein occlusion (CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these changes and best-corrected visual acuity (BCVA) and retinal thickness. METHODS: Twenty-eight eyes of 28 patients with macular edema caused by CRVO were included in this retrospective study. All patients received a single intravitreal conbercept injection to treat macular edema. BCVA and the results of optical coherence tomography angiography (OCTA) automatic measurements of the vessel density in the superficial (SCP) and deep retinal capillary plexus (DCP), the foveal avascular zone (FAZ) area, the FAZ perimeter (PERIM), the vessel density within a 300-μm wide ring surrounding the FAZ (FD-300), the acircularity index (AI), the choriocapillaris flow area, and retinal thickness were recorded before and at one month after treatment and compared with the results observed in age- and sex- matched healthy subjects. RESULTS: The vessel density in the SCP and DCP, the FD-300, and the flow area of the choriocapillaris were all significantly lower in CRVO eyes than in healthy eyes, while the AI and retinal thickness were significantly higher (all P
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