Beyond the WHO classification of meningioma: using molecular diagnostics to guide management

Autor: Abigail Clynch, George E Richardson, Mohammad A Mustafa, Conor S Gillespie, Nitika Rathi, Ali Bakhsh, Rasheed Zakaria, Abdurrahman I Islim, Christopher P Millward, Michael D Jenkinson
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Advances in Clinical Neuroscience & Rehabilitation, Vol , Iss (2023)
Druh dokumentu: article
ISSN: 1473-9348
2397-267X
DOI: 10.47795/WVJZ9783
Popis: Meningioma are the most common primary brain tumour. Classically, meningioma are phenotypically grouped using the World Health Organisation (WHO) classification system. However, it is now understood that the WHO approach overfits tumours into three grades, resulting in similarly graded tumours displaying phenotypically distinct behaviour. There is a growing body of research investigating the molecular biology of these tumours, including genomic, transcriptomic, metabolomic, proteomic, and methylomic profiling. Such advancements in molecular profiling of meningioma are providing greater accuracy in prognostication of tumours. Furthermore, a clearer understanding of tumour molecular biology highlights potential targets for pharmacotherapies. Currently, the routine application of in-depth tumour molecular analysis is limited, however as it becomes more widely available it will likely result in improved patient care. This review seeks to explore the important developments in meningioma molecular biology, discussed in the context of their clinical importance.
Databáze: Directory of Open Access Journals