| Autor: |
Ricardo Costa, Rubens B. Costa-Filho, Sarah M. Talamantes, Fernando Queiroga Jr, Emmanuel C. Campello, Henrique Cartaxo, Rubens B. Costa |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Case Reports in Oncology, Vol 10, Iss 2, Pp 524-530 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1662-6575 |
| DOI: |
10.1159/000477340 |
| Popis: |
Interstitial lung disease is a rare complication of trastuzumab-based breast cancer treatment with few case reports published. Herein, we report the case of a 67-year-old female with early-stage HER2-postitive breast cancer who developed interstitial pneumonitis during cycle 5 of treatment with trastuzumab combined with carboplatin and docetaxel. After supportive care and treatment with prednisone, the patient showed rapid improvement of respiratory symptoms. Retreatment with trastuzumab as a single agent led to worsening of symptoms and required a second course of treatment with prednisone combined with cyclophosphamide, which was followed by improvement of symptoms. In conclusion, interstitial pneumonitis is a rare but life-threatening adverse event from trastuzumab breast cancer treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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