Correlation between CXCR4, CXCR5 and CCR7 expression and survival outcomes in patients with clinical T1N0M0 non‐small cell lung cancer

Autor:	Zhao Yue, Ding Ningning, Yang Lin, Ying Jianming, Zhang Hongtu, Yuan Ligong, Li Feng, Wang Shuaibo, Mao Yousheng
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	CCR7 CXCR4 CXCR5 non‐small cell lung cancer survival outcome Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 11, Iss 10, Pp 2955-2965 (2020)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.13645
Popis:	Background Lung cancer is the leading cause of cancer‐related death. Even if early detection and treatment have proven to be effective, the survival outcomes are still poor. Methods Tissue samples and clinicopathological data of 244 patients with clinical T1N0M0 NSCLC were collected. We investigated CXCR4, CXCR5 and CCR7 expression levels using the immunohistochemical method and analyzed their correlations with clinicopathological characteristics and survival outcomes. Results Elevated expression levels of CXCR4, CXCR5 and CCR7 were found in tumor tissues (P
Databáze:	Directory of Open Access Journals
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