Urinary mitochondrial DNA level as a biomarker of tissue injury in non-diabetic chronic kidney diseases

Autor: Zhongping WEI, Bonnie Ching-Ha KWAN, Kai Ming CHOW, Phyllis Mei-Shan CHENG, Cathy Choi-Wan LUK, Ka-Bik LAI, Philip Kam-Tao LI, Cheuk Chun SZETO
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Nephrology, Vol 19, Iss 1, Pp 1-7 (2018)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/s12882-018-1178-9
Popis: Abstract Background Urinary mitochondrial DNA (mtDNA) fragment level has been proposed as a biomarker of chronic kidney disease (CKD). In this study, we determine the relation between urinary mtDNA level and rate of renal function deterioration in non-diabetic CKD. Methods We recruited 102 non-diabetic CKD patients (43 with kidney biopsy that showed non-specific nephrosclerosis). Urinary mtDNA level was measured and compared to baseline clinical and pathological parameters. The patients were followed 48.3 ± 31.8 months for renal events (need of dialysis or over 30% reduction in estimated glomerular filtration rate [eGFR]). Results The median urinary mtDNA level was 1519.42 (inter-quartile range 511.81–3073.03) million copy/mmol creatinine. There were significant correlations between urinary mtDNA level and baseline eGFR (r = 0.429, p
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