Autor: |
Zhongping WEI, Bonnie Ching-Ha KWAN, Kai Ming CHOW, Phyllis Mei-Shan CHENG, Cathy Choi-Wan LUK, Ka-Bik LAI, Philip Kam-Tao LI, Cheuk Chun SZETO |
Jazyk: |
angličtina |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
BMC Nephrology, Vol 19, Iss 1, Pp 1-7 (2018) |
Druh dokumentu: |
article |
ISSN: |
1471-2369 |
DOI: |
10.1186/s12882-018-1178-9 |
Popis: |
Abstract Background Urinary mitochondrial DNA (mtDNA) fragment level has been proposed as a biomarker of chronic kidney disease (CKD). In this study, we determine the relation between urinary mtDNA level and rate of renal function deterioration in non-diabetic CKD. Methods We recruited 102 non-diabetic CKD patients (43 with kidney biopsy that showed non-specific nephrosclerosis). Urinary mtDNA level was measured and compared to baseline clinical and pathological parameters. The patients were followed 48.3 ± 31.8 months for renal events (need of dialysis or over 30% reduction in estimated glomerular filtration rate [eGFR]). Results The median urinary mtDNA level was 1519.42 (inter-quartile range 511.81–3073.03) million copy/mmol creatinine. There were significant correlations between urinary mtDNA level and baseline eGFR (r = 0.429, p |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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