Synthesis and antiproliferative activity of 4H-chromonephenylhydrazones, 1H-pyrazolecarboxylates and pyrazolylmethanones
| Autor: | China Raju Bhimapaka, Nageswara Rao Rayala, Rajkumar Kommera, Dayakar Cherupally, Ramalinga Murthy Thampunuri, V Kalivendi Shasi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Acta Chimica Slovenica, Vol 65, Iss 1, Pp 34-49 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1318-0207 1580-3155 |
| DOI: | 10.17344/acsi.2017.3453 |
| Popis: | Series of 4H-chromone-based hydrazones 3a–z, pyrazolecarboxylates 5a–x and pyrazolylmethanones 6a–u were prepared and screened for their anti-proliferative activity on A549, HeLa, DU145 and MDAMB 231 cell lines. The hydrazone compound 3s with a chloro substituent on the chromanone moiety and a methoxy group on the phenyl ring displayed promising activity on A549, HeLa and DU145 cell lines. The compound 5p with a bromo substituent on the chromanone moiety and a methyl group on the phenyl ring displayed potent activity on DU145. Furopyrazolecarboxylate 5w having a methyl substituent on the phenyl ring displayed potent activity on HeLa cell line. The pyrazolylmethanone 6e with a fluoro substituent on the phenyl ring and compound 6j having a methyl substituent on the chromanone moiety and a methoxy group on the phenyl ring have shown promising anti-proliferative activity on HeLa cell line. |
| Databáze: | Directory of Open Access Journals |
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