Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

Autor: Abigail S. L. Sudol, John Butler, Dylan P. Ivory, Ivo Tews, Max Crispin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-35340-z
Popis: The streptococcal enzymes IdeS and EndoS cleave IgG antibodies with exquisite substrate specificity, which has enabled their development as clinical and biotechnological tools. Here, the authors present crystal structures of both enzymes in complex with their IgG1 Fc substrate.
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