Prevalence of ECG abnormalities and risk factors for QTc interval prolongation in hospitalized psychiatric patients
| Autor: | Nicolas Ansermot, Meredith Bochatay, Jürg Schläpfer, Mehdi Gholam, Ariane Gonthier, Philippe Conus, Chin B Eap |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Psychopharmacology, Vol 9 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2045-1261 20451253 |
| DOI: | 10.1177/2045125319891386 |
| Popis: | Background: Psychiatric patients are at risk of cardiovascular diseases, and many psychotropic drugs can prolong QTc interval. Requirements for electrocardiogram (ECG) monitoring have been set up in our psychiatric university hospital. The objective of this study was to determine the proportion of adult patients who had an ECG during their hospitalization, the prevalence of ECG abnormalities, the evolution of the QTc after admission, and the risk factors for QTc prolongation. Methods: Retrospective analysis of ECGs and clinical data of all patients with a complete hospitalization in 2015. Assessment of the influence of covariates on QTc using linear mixed-effects models. Results: At least one ECG ( n = 600) was performed during 37.6% of the stays ( n = 1198) and in 45.5% of the patients ( n = 871). Among the patients with an ECG, 17.9% had significant ECG abnormalities, including 7.6% with a prolonged QTc. QTc measured at admission and during hospitalization did not change significantly ( n = 46, 419.4 ± 29.7 ms, 417.2 ± 27.6 ms, p = 0.71). In the multivariate model (292 patients, 357 ECGs), the covariates significantly associated with the QTc were gender (+15.9 ms if female, p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|