The Effect of Fatty Acids and BSA Purity on Synthesis and Properties of Fluorescent Gold Nanoclusters

Autor: Pavlína Andrýsková, Karolína Machalová Šišková, Šárka Michetschlägerová, Klára Jiráková, Martin Kubala, Daniel Jirák
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nanomaterials, Vol 10, Iss 2, p 343 (2020)
Druh dokumentu: article
ISSN: 2079-4991
DOI: 10.3390/nano10020343
Popis: Fluorescent gold nanoclusters (AuNCs) are envisaged as a novel type of fluorophores. This work reports on the first comparative study investigating the effect of presence/absence/abundance of fatty acids (namely palmitic acid, PA) or other substances (like glycoproteins and globulins) in the protein (bovine serum albumin, BSA) on synthesis and properties of the final AuNCs. The most popular template (BSA) and microwave (MW)-assisted synthesis of AuNCs have been intentionally chosen. Our results clearly demonstrate that the fluorescent characteristics (i.e., fluorescence lifetime and quantum yield) are affected by the fatty acids and/or other substances. Importantly, the as-prepared AuNCs are biocompatible, as determined by Alamar Blue assay performed on Hep G2 cell line.
Databáze: Directory of Open Access Journals