| Autor: |
Pamela Paglia, Lucia Nazzaro, Anna Giulia Elena De Anseris, Milena Lettieri, Rossella Colantuono, Maria Chiara Rocco, Maria Anna Siano, Nicola Biffaro, Pietro VAJRO |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Pediatric Reports, Vol 13, Iss 3, Pp 357-362 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2036-7503 |
| DOI: |
10.3390/pediatric13030044 |
| Popis: |
Hypertransaminasemia in patients with Kawasaki disease (KD) is reported to be transient. Here, we describe a child with an atypically protracted course of liver tests abnormalities and review the inherent literature. The patient was hospitalized at age 7-months for isolated hypertransaminasemia detected during a classical KD diagnosed 3 months before, and persistent since then. KD clinical evolution had been favorable, with rapid response to acetylsalicylic acid and intravenous immunoglobulins. Liver enzymes however remained persistently elevated with a fluctuating pattern (ALT > AST levels; peak of AST 186 IU/L and ALT 240 IU/L). During follow-up, the main causes of liver dysfunction had to be excluded through appropriate and extensive laboratory investigations. Transaminases values become steadily normal only 7 months after the acute presentation of KD. Conclusions: Our report shows that an atypically protracted courses of KD-related hypertransaminasemia above the previously reported temporal limits should be taken into account during the stepwise diagnostic approach to the patient’s liver dysfunction. Insidious acetylsalycilic acid-hepatotoxicity warrants consideration in the differential diagnosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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