Antibacterial Effects of Basil (Ocimum sanctum) Leaf Extract in Combination with Meropenem against Extended Spectrum Beta-Lactamase (ESBL) Producing Klebsiella pneumoniae
| Autor: | Billy Yanssen Lifindra, Nurul Wiqoyah, Danti Nur Indiastuti |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, Vol 15, Iss 2, Pp 88-93 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1907-3623 2684-9453 |
| DOI: | 10.20473/juxta.V15I22024.88-93 |
| Popis: | Introduction: Antibiotic usage for bacterial infections causes antibiotic resistance in bacteria. One is extended-spectrum beta-lactamase (ESBL), which produces Klebsiella pneumoniae, a pathogen responsible for increased antibiotic resistance. Basil (Ocimum sanctum) is a candidate for combination therapy. It has been proven to have antibacterial effects. However, its combination with antibiotics is rarely researched. This study evaluated the antibacterial effects of O. sanctum leaf extract and meropenem combination against ESBL-producing K. pneumoniae. Methods: This study used the disk diffusion method. The extract was tested for each experiment at 6%, 4%, 2%, 1%, and 0.5% concentration. The research was divided into two experiments to evaluate the antibacterial effects of O. sanctum leaf extract (n=18) and its combination with meropenem against ESBL-producing K. pneumoniae (n=18). The data was analyzed using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 26.0 for Windows. A probability p |
| Databáze: | Directory of Open Access Journals |
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