Simultaneous Quantitative Estimation of Lisinopril and Hydrochlorothiazide Residues Using HPLC for Cleaning Validation

Autor:	Imeda Rubashvili, Natela Karukhnishvili, Khatuna Makharadze
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	lisinopril hydrochlorthiazide swab sampling rinse sampling hplc validation Chemistry QD1-999 General. Including alchemy QD1-65
Zdroj:	Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, Vol 15, Iss 1, Pp 8-21 (2020)
Druh dokumentu:	article
ISSN:	1857-1727 2345-1688
DOI:	10.19261/cjm.2020.669
Popis:	A new, rapid and selective, HPLC method for simultaneous quantitative estimation of lisinopril and hydrochlorothiazide residues and sampling procedures from pharmaceutical manufacturing equipment surfaces were developed and validated. The sampling procedures have a good recovery (>80%). The limit of quantitation of the HPLC method - 0.155 µg/mL and 0.025 µg/mL for lisinopril and hydrochlorothiazide, respectively.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d789c1a8a46c49fa91d736281449d259 Zobrazit plný text záznamu View record in DOAJ