Cuttlefish Bone-Derived Calcium Phosphate Bioceramics Have Enhanced Osteogenic Properties

Autor: Boqi Pang, Jiaru Xian, Jiajun Chen, Liqi Ng, Mengting Li, Guangchun Zhao, Yixun E, Xiaorui Wang, Xiaxin Cao, Changze Zhang, Mingjing Zhang, Chaozong Liu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Functional Biomaterials, Vol 15, Iss 8, p 212 (2024)
Druh dokumentu: article
ISSN: 2079-4983
DOI: 10.3390/jfb15080212
Popis: Cuttlefish bones are byproducts of cuttlefish processing and are readily available in the marine food industry. In this study, calcium phosphate bioceramics were prepared from cuttlefish bones using a two-stage hydrothermal calcination process. The results indicated that all bioceramics derived from cuttlefish bones had a higher degradation capacity, better bone-like apatite formation ability, and higher degree of osteogenic differentiation than commercially available hydroxyapatite. Notably, β-tricalcium phosphate, which had the highest degree of Ca2+ and Sr2+ dissolution among the bioceramics extracted, can significantly upregulate osteogenic markers (alkaline phosphatase, osteocalcin) and stimulate bone matrix mineralization. Thus, it is a promising bioceramic material for applications in bone regeneration.
Databáze: Directory of Open Access Journals