ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
| Autor: | Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xia-Nan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming-Ming Hu, Cao-Qi Lei, Wei-Wei Luo, Shu Li, Hong-Bing Shu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 46425144 |
| DOI: | 10.1038/s41467-018-05559-w |
| Popis: | cGAS is an important mediator of antiviral immune responses, but the regulation of its activity is unknown. Here, the authors identify a zinc finger protein, ZCCHC3, that enhances the binding of cGAS to dsDNA and is important for its activation following viral infection. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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