Enhanced oral bioavailability and tissue distribution of ferric citrate through liposomal encapsulation

Autor: Li Yuan, Xiu Ji, Jun Chen, Mingyong Xie, Lina Geng, Ruichang Gao
Jazyk: English<br />Spanish; Castilian
Rok vydání: 2017
Předmět:
Zdroj: CyTA - Journal of Food, Vol 15, Iss 1, Pp 136-142 (2017)
Druh dokumentu: article
ISSN: 1947-6337
1947-6345
19476337
DOI: 10.1080/19476337.2016.1221858
Popis: Our previous study found that ferric citrate-loaded liposome (FAC-LIP) exhibited stable physical characteristics and have better efficacy to treat anemia of inflammation (AI) than free ferric citrate (FAC). This study was aimed at oral pharmacokinetics of both FAC-LIP and FAC in Sprague Dawley (SD) rats. Results showed that the main pharmacokinetic parameters of FAC-LIP in vivo were as follows: Cmax of 445.89 ± 23.56 μg/mL, Tmax of 4 h, t1/2 of 13.01 ± 2.04 h, MRT of 20.54 ± 2.06 h and AUC0-24 h of 6446.1 ± 516.58 hμg/mL. The relative bioavailability of FAC-LIP formulation was 215.7%, nearly 2-fold in comparison with free FAC formulation. FAC-LIP showed a sustained-release effect, a wide absorption and a complete elimination. These results support the fact that FAC-LIP has the potential of improving oral bioavailability and reducing iron accumulation in liver, which could influence the available iron level in the blood system. FAC-LIP could be used as an effective iron supplement.
Databáze: Directory of Open Access Journals
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