Different immune contextures underlie tumor site‐specific responses to immune checkpoint blockade in esophageal cancer

Autor:	Jhe‐Cyuan Guo, Chia‐Lang Hsu, Min‐Shu Hsieh, Chia‐Chi Lin, Ta‐Chen Huang, Hung‐Yang Kuo, Yu‐Yun Shao, Chih‐Hung Hsu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	differential response esophageal squamous cell carcinoma immune checkpoint inhibitor immune contexture tumor site specific Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 14, Iss 22, Pp 2216-2221 (2023)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.14997
Popis:	Abstract Immune checkpoint inhibitors (ICIs) have demonstrated efficacy in advanced esophageal squamous cell carcinoma (ESCC). Heterogeneous responses to ICIs have been reported previously. Here, we describe a patient with advanced ESCC exhibiting a response to durvalumab plus tremelimumab for more than 6 months except primary resistant esophageal tumor. The esophageal tumor had higher regulatory T cells, neutrophils, and mast cells scores estimated by NanoString platform than hepatic tumor. The immunohistochemistry study confirmed higher expression levels of Foxp3, and myeloperoxidase (MPO) in the esophageal tumor. The different immune contextures may underlie the heterogeneous responses to ICI combination in this ESCC patient.
Databáze:	Directory of Open Access Journals
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