Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
| Autor: | Hugo Amorim dos Santos de Souza, Victor Fernandes Escafa, Carolina Moreira Blanco, Bárbara de Oliveira Baptista, Jenifer Peixoto de Barros, Evelyn Ketty Pratt Riccio, Aline Beatriz Mello Rodrigues, Gisely Cardoso de Melo, Marcus Vinícius Guimarães de Lacerda, Rodrigo Medeiros de Souza, Josué da Costa Lima-Junior, Ana Carolina Ramos Guimarães, Fabio Faria da Mota, João Hermínio Martins da Silva, Cláudio Tadeu Daniel-Ribeiro, Lilian Rose Pratt-Riccio, Paulo Renato Rivas Totino |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 116 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1678-8060 0074-0276 |
| DOI: | 10.1590/0074-02760200584 |
| Popis: | In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain in two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among all P. vivax field isolates and the Sal-1 reference strain. Analysis of PvMCA1 catalytic domain in different P. vivax genomic sequences publicly available also revealed a high degree of conservation worldwide, with very few amino acid substitutions that were not related to putative histidine and cysteine catalytic residues, whose involvement with the active site of protease was herein predicted by molecular modeling. The genetic conservation presented by PvMCA1 may contribute to its eligibility as a druggable target candidate in vivax malaria. |
| Databáze: | Directory of Open Access Journals |
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