A novel scale based on biomarkers associated with COVID-19 severity can predict the need for hospitalization and intensive care, as well as enhanced probabilities for mortality

Autor: Eduardo Nieto-Ortega, Alejandro Maldonado-del-Arenal, Lupita Escudero-Roque, Diana Ali Macedo-Falcon, Ana Elena Escorcia-Saucedo, Adalberto León-del-Ángel, Alejandro Durán-Méndez, María José Rueda-Medécigo, Karla García-Callejas, Sergio Hernández-Islas, Gabriel Romero-López, Ángel Raúl Hernández-Romero, Daniela Pérez-Ortega, Estephany Rodríguez-Segura, Daniela Montaño‑Olmos, Jeffrey Hernández-Muñoz, Samuel Rodríguez-Peña, Montserrat Magos, Yanira Lizeth Aco-Cuamani, Nazareth García-Chávez, Ana Lizeth García-Otero, Analiz Mejía-Rangel, Valeria Gutiérrez-Losada, Miguel Cova-Bonilla, Alma Delia Aguilar-Arroyo, Araceli Sandoval-García, Eneyda Martínez-Francisco, Blanca Azucena Vázquez-García, Aldo Christiaan Jardínez-Vera, Alejandro Lechuga-Martín del Campo, Alberto N. Peón
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-023-30913-4
Popis: Abstract Prognostic scales may help to optimize the use of hospital resources, which may be of prime interest in the context of a fast spreading pandemics. Nonetheless, such tools are underdeveloped in the context of COVID-19. In the present article we asked whether accurate prognostic scales could be developed to optimize the use of hospital resources. We retrospectively studied 467 files of hospitalized patients after COVID-19. The odds ratios for 16 different biomarkers were calculated, those that were significantly associated were screened by a Pearson’s correlation, and such index was used to establish the mathematical function for each marker. The scales to predict the need for hospitalization, intensive-care requirement and mortality had enhanced sensitivities (0.91 CI 0.87–0.94; 0.96 CI 0.94–0.98; 0.96 CI 0.94–0.98; all with p
Databáze: Directory of Open Access Journals
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