| Autor: |
Aurelio Lopez, Maria-Victoria Mateos, Albert Oriol, Marta Valero, Joaquín Martínez, Jose Ignacio Lorenzo, Montserrat Perez, Rafael Martinez, Raquel de Paz, Miguel Granell, Felipe De Arriba, M. Jesús Blanchard, Francisco Javier Peñalver, Jose Luis Bello, Maria Luisa Martin, Joan Bargay, Joan Blade, Juan Jose Lahuerta, Jesús F. San Miguel, Javier de la Rubia |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Leukemia Research Reports, Vol 4, Iss 2, Pp 64-69 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0489 |
| DOI: |
10.1016/j.lrr.2015.09.002 |
| Popis: |
We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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