| Autor: |
Masahiro Yamashita, Yujiro Yoshihara, Ryuichiro Hashimoto, Noriaki Yahata, Naho Ichikawa, Yuki Sakai, Takashi Yamada, Noriko Matsukawa, Go Okada, Saori C Tanaka, Kiyoto Kasai, Nobumasa Kato, Yasumasa Okamoto, Ben Seymour, Hidehiko Takahashi, Mitsuo Kawato, Hiroshi Imamizu |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
eLife, Vol 7 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2050-084X |
| DOI: |
10.7554/eLife.38844 |
| Popis: |
Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared across diseases or a set of discrete dysfunctions. Here, we performed predictive modeling to examine working memory ability (WMA) as a function of normative whole-brain connectivity across psychiatric diseases. We built a quantitative model for letter three-back task performance in healthy participants, using resting state functional magnetic resonance imaging (rs-fMRI). This normative model was applied to independent participants (N = 965) including four psychiatric diagnoses. Individual’s predicted WMA significantly correlated with a measured WMA in both healthy population and schizophrenia. Our predicted effect size estimates on WMA impairment were comparable to previous meta-analysis results. These results suggest a general association between brain connectivity and working memory ability applicable commonly to health and psychiatric diseases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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