| Autor: |
Mikael Roussel, Juliette Ferrant, Florian Reizine, Simon Le Gallou, Joelle Dulong, Sarah Carl, Matheiu Lesouhaitier, Murielle Gregoire, Nadège Bescher, Clotilde Verdy, Maelle Latour, Isabelle Bézier, Marie Cornic, Angélique Vinit, Céline Monvoisin, Birgit Sawitzki, Simon Leonard, Stéphane Paul, Jean Feuillard, Robin Jeannet, Thomas Daix, Vijay K. Tiwari, Jean Marc Tadié, Michel Cogné, Karin Tarte |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cell Reports Medicine, Vol 2, Iss 6, Pp 100291- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3791 |
| DOI: |
10.1016/j.xcrm.2021.100291 |
| Popis: |
Summary: Acute respiratory distress syndrome (ARDS) is the main complication of coronavirus disease 2019 (COVID-19), requiring admission to the intensive care unit (ICU). Despite extensive immune profiling of COVID-19 patients, to what extent COVID-19-associated ARDS differs from other causes of ARDS remains unknown. To address this question, here, we build 3 cohorts of patients categorized in COVID-19−ARDS+, COVID-19+ARDS+, and COVID-19+ARDS−, and compare, by high-dimensional mass cytometry, their immune landscape. A cell signature associating S100A9/calprotectin-producing CD169+ monocytes, plasmablasts, and Th1 cells is found in COVID-19+ARDS+, unlike COVID-19−ARDS+ patients. Moreover, this signature is essentially shared with COVID-19+ARDS− patients, suggesting that severe COVID-19 patients, whether or not they experience ARDS, display similar immune profiles. We show an increase in CD14+HLA-DRlow and CD14lowCD16+ monocytes correlating to the occurrence of adverse events during the ICU stay. We demonstrate that COVID-19-associated ARDS displays a specific immune profile and may benefit from personalized therapy in addition to standard ARDS management. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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