Impact of atrial fibrillation on pulmonary embolism hospitalization: Nationwide analysis

Autor: Mubarak Hassan Yusuf, Akanimo Anita, Olayiwola Akeem Bolaji, Faridat Moyosore Abdulkarim, Chibuike Daniel Onyejesi, Maryam Yusuf, Utku Ekin, Arham Syed Hazari, Mourad Ismail
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: American Heart Journal Plus, Vol 46, Iss , Pp 100465- (2024)
Druh dokumentu: article
ISSN: 2666-6022
DOI: 10.1016/j.ahjo.2024.100465
Popis: Introduction: Atrial fibrillation (AF) is the most common type of arrythmia affecting approximately 1–2 % of the adult population. Patients with an underlying history of atrial fibrillation have a greater chance of developing venous thromboembolism (VTE). Likewise, patients with VTE are at increased risk for AF. There has been conflicting evidence on the prognostic impact of AF in acute pulmonary embolism (PE) patients. The aim of this retrospective cohort study was to estimate the impact of AF on the clinical outcomes of hospitalization for PE. Method: The 2016–2021 National Inpatient Sample database was searched for adult patients hospitalized with PE with associated history of AF as the principal discharge diagnosis. The primary outcome was inpatient mortality, while the secondary outcomes were length of stay (LOS), total hospital charge (THC), cardiogenic shock, acute respiratory failure, in-hospital cardiac arrest (IHCA). The outcomes were analyzed using multivariable logistic and linear regression analyses. Results: A total of 1,128,269 patients were admitted for PE, 12.4 % of whom had underlying AF. The AF and non-AF cohorts had a mean age of 73.6 years and 61.6 years, respectively. PE patient with AF had significantly higher mortality compared to non-AF patients with PE (6.05 % vs 2.75 %, adjusted odds ratio of 1.67 [95 % CI 1.56–1.79; p
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