Highly Pathogenic Clone of Shiga Toxin–Producing Escherichia coli O157:H7, England and Wales

Autor:	Lisa Byrne, Timothy J. Dallman, Natalie Adams, Amy F.W. Mikhail, Noel McCarthy, Claire Jenkins
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Shiga toxin–producing Escherichia coli whole-genome sequencing virulence evolution bacteria enteric infections Medicine Infectious and parasitic diseases RC109-216
Zdroj:	Emerging Infectious Diseases, Vol 24, Iss 12, Pp 2303-2308 (2018)
Druh dokumentu:	article
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2412.180409
Popis:	We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin–producing Escherichia coli (STEC) O157:H7 in England and Wales. A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative ancestor ≈10 years ago after acquisition of a bacteriophage encoding Shiga toxin (stx) 2a, which in turn had evolved from a stx2c progenitor ≈20 years ago. Infection with the stx2a clone was a significant risk factor for bloody diarrhea (OR 4.61, 95% CI 2.24–9.48; p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c78550fdc07748f091b923084dc82b63 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF