Adjunctive Sitagliptin Therapy in Postoperative Cardiac Surgery Patients: A Pilot Study
| Autor: | Marcia L. Brackbill, Ateequr Rahman, Jeffrey S. Sandy, M. Denton Stam, Arthur F. Harralson |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | International Journal of Endocrinology, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1687-8337 1687-8345 |
| DOI: | 10.1155/2012/810926 |
| Popis: | Aim. We aimed to determine if sitagliptin added to standard postoperative standardized sliding-scale insulin regimens improved blood glucose. Methods. A prospective, randomized, double-blind, placebo-controlled pilot study was conducted in diabetic cardiac surgery patients. Patients received sitagliptin or placebo after surgery for 4 days. The primary endpoint was to estimate the effect of adjunctive sitagliptin versus placebo on overall mean blood glucose in the 4-day period after surgery. Results. Sixty-two patients participated. Repeated measures tests indicated no significant difference between the groups in the overall mean blood glucose level with a mean of 147.2±4.8 mg/dL and 153.0±4.6 mg/dL for the test and the control group, respectively (P=0.388). Conclusions. Sitagliptin added to normal postoperative glucose management practices did not improve overall mean blood glucose control in diabetic patients in the postoperative setting. |
| Databáze: | Directory of Open Access Journals |
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