Human papillomavirus infections in low‐grade squamous intraepithelial lesion in Peruvian pregnant woman: A cross‐sectional cytology‐based study

Autor: Jeel Moya‐Salazar, Víctor Rojas‐Zumaran, Omar Bravo L., Gonzalo Moscoso, Hans Contreras‐Pulache
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Health Science Reports, Vol 5, Iss 6, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2398-8835
DOI: 10.1002/hsr2.835
Popis: Abstract Background and Aims Low‐risk human papillomaviruses (HPV) are important in pregnant women because they are risk factors for Condyloma acuminatum and recurrent respiratory papillomatosis in the newborn. On the other hand, HPV may contribute to the development of preneoplastic lesions such as LSIL in pregnant women. We aimed to assess the frequency of HPV infections in low‐grade squamous intraepithelial lesion (LSIL) in Peruvian pregnant women. Methods A cross‐sectional study was conducted from 2011 to 2015 in 84 primiparous‐ and multiparous pregnant women (mean age: 27 ± 6.3 years). Pregnant women of 18–45 years attending gynecology outpatient department were included for the study. LSIL and HPV (nuclear irregularities, koilocytosis, and cytopathic effect) cellular alterations were reported using the Bethesda System guidelines. Results Sixty‐four percent had cytological HPV infection (koilocytes and/or pathognomonic signs of infection) and more than a half of pregnant women had a previous Pap test. LSIL was more frequent in multiparous (increased by 12%, p = 0.008), in the second and third trimester (60.7%, p = 0.002), and between the ages of 18 and 30 (42 cases (50%), p = 0.110). This proportion was significatively increased in women with ≥2 sexual partners (39.3%), with an early onset of first intercourse, and from the Rímac Municipality (14.3%) (p
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