| Autor: |
Claudia Lancey, Muhammad Tehseen, Vlad-Stefan Raducanu, Fahad Rashid, Nekane Merino, Timothy J. Ragan, Christos G. Savva, Manal S. Zaher, Afnan Shirbini, Francisco J. Blanco, Samir M. Hamdan, Alfredo De Biasio |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-14898-6 |
| Popis: |
Pol δ bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand in eukaryotes and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. Here, the authors present a Cryo-EM structure of the human 4-subunit Pol δ bound to DNA and PCNA in a replicating state with an incoming nucleotide in the active site. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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