| Autor: |
Frank Preiswerk, Meera S. Sury, Jeremy R. Wortman, Gesa Neumann, William Wells, Jeffrey Duryea |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Osteoarthritis and Cartilage Open, Vol 4, Iss 1, Pp 100234- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2665-9131 |
| DOI: |
10.1016/j.ocarto.2022.100234 |
| Popis: |
Objective: Knee osteoarthritis (KOA) is a prevalent disease with a high economic and social cost. Magnetic resonance imaging (MRI) can be used to visualize many KOA-related structures including bone marrow lesions (BMLs), which are associated with OA pain. Several semi-automated software methods have been developed to segment BMLs, using manual, labor-intensive methods, which can be costly for large clinical trials and other studies of KOA. The goal of our study was to develop and validate a more efficient method to quantify BML volume on knee MRI scans. Materials and methods: We have applied a deep learning approach using a patch-based convolutional neural network (CNN) which was trained using 673 MRI data sets and the segmented BML masks obtained from a trained reader. Given the location of a BML provided by the reader, the network performed a fully automated segmentation of the BML, removing the need for tedious manual delineation. Accuracy was quantified using the Pearson's correlation coefficient, by a comparison to a second expert reader, and using the Dice Similarity Score (DSC). Results: The Pearson's R2 value was 0.94 and we found similar agreement when comparing two readers (R2 = 0.85) and each reader versus the DL model (R2 = 0.95 and R2 = 0.81). The average DSC was 0.70. Conclusions: We developed and validated a deep learning-based method to segment BMLs on knee MRI data sets. This has the potential to be a valuable tool for future large studies of KOA. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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