Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain

Autor: Gui-Fang Duan, Yaxin Ye, Sha Xu, Wucheng Tao, Shiping Zhao, Tengchuan Jin, Roger A. Nicoll, Yun Stone Shi, Nengyin Sheng
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-07403-7
Popis: The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies surface expression and trafficking.
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