Surgical treatment and clinicopathological characteristics of patients with neuroendocrine neoplasms of the stomach

Autor: V Yu Bokhyan, I N Peregorodiev, V V Delektorskaya, P P Arkhiri, I S Stilidi
Jazyk: ruština
Rok vydání: 2016
Předmět:
Zdroj: Современная онкология, Vol 18, Iss 4, Pp 34-41 (2016)
Druh dokumentu: article
ISSN: 1815-1434
1815-1442
Popis: Neuroendocrine neoplasms of the stomach combine a wide range of tumors with different clinical features and prognosis. They are systematized by three classifications: WHO Classification, clinicopathological classification, TNM classification (UICC, ENETs). The treatment of stomach NENs is still unclear. Surgical method is the main treatment for localized forms and the only one way that can help to achieve a complete cure in patients with NENs. Patients and methods. The results of treatment of 35 patients with gastric NENs who were operated at N.N.Blokhin Russian Cancer Research Center for the period of time from 2001 to 2015 were analyzed. The patients were divided into two groups: well-differentiated tumors (1 and 3 clinicopathological types), poor-differentiated tumors - neuroendocrine cancer. Gender, age of patients, clinical features, type of tumors, locations and number of tumor, stage, time from manifestation to diagnosis, type of surgery, Ki-67 index, five-year survival rate were analyzed. Results. Surgical treatment allows to achieve a good result for the group of patients with well-differentiated tumors of stomach (where EMR is not recommended). The overall five-year survival rate is 79.8%. In the group of patients with NEC of the stomach radical surgery allows you to achieve the best five-year survival compared to palliative (54.8 and 0%, p=0.03, log-rank). Conclusions. The group of patients with well-differentiated neuroendocrine tumors is heterogeneous and requires a more careful and differentiated treatment approach. The main principles for the selection are clinicopathological features and proliferative index. According to our research, the value of Ki-67 to precises determine G1 and G2 is 5%. Surgical treatment allows to achieve the good long-term results for patients with localized NECs of the stomach.
Databáze: Directory of Open Access Journals
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