Serum hyaluronic acid and procollagen III, N-terminal propeptide levels are highly associated with disease severity and predict the progression of COVID-19

Autor: Ti Yang, Le Le Liu, Xin Han Wu, Jian Guo Xue, Chun Yan He
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Druh dokumentu: article
ISSN: 2235-2988
DOI: 10.3389/fcimb.2023.1249038
Popis: BackgroundThe coronavirus disease 2019 (COVID-19) pandemic is a rapidly evolving global emergency and continuously poses a serious threat to public health, highlighting the urgent need of identifying biomarkers for disease severity and progression. In order to early identify severe and critical patients, we retrospectively analyze the clinical characteristics and risk indicators of severe disease in patients with corona virus disease 2019 (COVID-19).MethodsA total of 420 confirmed COVID-19 patients were included in the study. According to the “Diagnosis and Treatment of novel coronavirus Pneumonia (10th Edition)”, the cases were divided into mild group (n = 243) and severe group (n =177). Laboratory parameters were analyzed in combination with clinical data.ResultsMale patients over 46 years who have smoking habits were more likely to suffer from severe COVID-19. Critically ill patients had lower lymphocyte counts and red blood cell counts, and higher white blood cell counts (P
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