Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition

Autor: Chengying Ma, Damu Wu, Qian Chen, Ning Gao
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34511-2
Popis: Drg1 is a cytoplasmic AAA + ATPase responsible for releasing Rlp24 during ribosome assembly. Here, the authors show that Drg1 structurally and functionally shares many regulatory features with that of Cdc48/p97, suggesting a unfoldase role for Drg1.
Databáze: Directory of Open Access Journals