| Autor: |
Nader Kim El-Mallawany, Jimmy Villiera, William Kamiyango, Erin C. Peckham-Gregory, Michael E. Scheurer, Carl E. Allen, Casey L. McAtee, Alejandra Legarreta, Dirk P. Dittmer, Carrie L. Kovarik, Elizabeth Y. Chiao, Stephen C. Martin, Nmazuo W. Ozuah, Parth S. Mehta, Peter N. Kazembe |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Infectious Agents and Cancer, Vol 13, Iss 1, Pp 1-7 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1750-9378 |
| DOI: |
10.1186/s13027-018-0207-4 |
| Popis: |
Abstract Background Endemic Kaposi sarcoma (KS) was first described in African children over fifty years ago, but has recently been overshadowed by HIV-related disease. We aimed to evaluate the similarities and differences between endemic HIV-negative and epidemic HIV-positive pediatric KS in a KS-associated herpesvirus-endemic region of Africa. Methods We describe clinical characteristics of 20 HIV-negative children with endemic KS over a six-year period and compare findings with a historical control—an HIV-related pediatric KS cohort from Lilongwe, Malawi. Results The HIV-negative endemic KS cohort was 70% male with a median age of 9.3 years. Lymph node involvement was present in 50%, hyperpigmented skin lesions in 45%, and woody edema in 40%. One patient (5%) presented with oral KS involvement and no patients presented initially with visceral KS. Significant anemia (hemoglobin |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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