Drug Delivery with Polymeric Nanocarriers—Cellular Uptake Mechanisms
| Autor: | Levi Collin Nelemans, Leonid Gurevich |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
drug delivery systems
endocytosis polymeric micelles amphiphilic block copolymers nanoparticles drug release Technology Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 |
| Zdroj: | Materials, Vol 13, Iss 2, p 366 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1996-1944 13020366 |
| DOI: | 10.3390/ma13020366 |
| Popis: | Nanocarrier-based systems hold a promise to become “Dr. Ehrlich’s Magic Bullet” capable of delivering drugs, proteins and genetic materials intact to a specific location in an organism down to subcellular level. The key question, however, how a nanocarrier is internalized by cells and how its intracellular trafficking and the fate in the cell can be controlled remains yet to be answered. In this review we survey drug delivery systems based on various polymeric nanocarriers, their uptake mechanisms, as well as the experimental techniques and common pathway inhibitors applied for internalization studies. While energy-dependent endocytosis is observed as the main uptake pathway, the integrity of a drug-loaded nanocarrier upon its internalization appears to be a seldomly addressed problem that can drastically affect the uptake kinetics and toxicity of the system in vitro and in vivo. |
| Databáze: | Directory of Open Access Journals |
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