Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior.

Autor: Haitao Wang, Jiahui Chen, Xiaotong Xu, Wen-Jian Sun, Xi Chen, Fei Zhao, Min-Hua Luo, Chunhua Liu, Yiping Guo, Wen Xie, Hui Zhong, Tongjian Bai, Yanghua Tian, Yu Mao, Chonghuan Ye, Wenjuan Tao, Jie Li, Zahra Farzinpour, Juan Li, Jiang-Ning Zhou, Kai Wang, Jufang He, Lin Chen, Zhi Zhang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: PLoS Biology, Vol 17, Iss 8, p e3000417 (2019)
Druh dokumentu: article
ISSN: 1544-9173
1545-7885
DOI: 10.1371/journal.pbio.3000417
Popis: Threatening sounds can elicit a series of defensive behavioral reactions in animals for survival, but the underlying neural substrates are not fully understood. Here, we demonstrate a previously unexplored neural pathway in mice that projects directly from the auditory cortex (ACx) to the lateral periaqueductal gray (lPAG) and controls noise-evoked defensive behaviors. Electrophysiological recordings showed that the lPAG could be excited by a loud noise that induced an escape-like behavior. Trans-synaptic viral tracing showed that a great number of glutamatergic neurons, rather than GABAergic neurons, in the lPAG were directly innervated by those in layer V of the ACx. Activation of this pathway by optogenetic manipulations produced a behavior in mice that mimicked the noise-evoked escape, whereas inhibition of the pathway reduced this behavior. Therefore, our newly identified descending pathway is a novel neural substrate for noise-evoked escape and is involved in controlling the threat-related behavior.
Databáze: Directory of Open Access Journals
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