Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy
| Autor: | Yuqing Zhou, Qian Dong, Rong Zhang, Shunfeng Zhou, Linqiang Li, Keran Cheng, Rui Kong, Qiang Yu, Shizan Xu, Jingjing Li, Sainan Li, Jiao Feng, Liwei Wu, Tong Liu, Xiya Lu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Chuanyong Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Gastroenterology Research and Practice, Vol 2016 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1687-6121 1687-630X |
| DOI: | 10.1155/2016/8485032 |
| Popis: | Aims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among ammonia, cerebral hemodynamics, and cognitive function. Methods. There were four groups: healthy controls (group 1), cirrhosis without HE (group 2), cirrhosis with MHE (group 3), and cirrhosis with OHE (group 4). Ammonia and cerebral hemodynamics (by TCD) were assessed. Patients in group 3 were subsequently randomized to two subgroups: the control (group A) and the treated (group B, treated with lactulose for two months), and they were retested for ammonia and TCD after treatment. Results. Ammonia, Vm, Vd, PI, and RI were statistically different before treatment, and ammonia, PI, and RI levels paralleled the severity of HE (P0.05). Correlations were found between ammonia and Vd, PI, RI, NCT-A, and DST and also found between Vd, PI, RI, and NCT-A and DST (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|