Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study

Autor: Ximing Wang, Jingxiang Sun, Na Chang, Menghan Liu, Shuai Zhang
Jazyk: angličtina
Rok vydání: 2025
Předmět:
Zdroj: BMC Medical Imaging, Vol 25, Iss 1, Pp 1-9 (2025)
Druh dokumentu: article
ISSN: 1471-2342
DOI: 10.1186/s12880-025-01559-7
Popis: Abstract Background The purpose of our study was to investigate the association between non-alcoholic fatty liver disease (NAFLD) and abdominal aortic aneurysms (AAA) progression using non-enhanced computed tomography (CT) and CT angiography (CTA). Methods Patients with AAA and age- and sex-matched healthy subjects who underwent abdominal CTA and non-enhanced CT examination between January 2015 and January 2023 from four hospitals were retrospectively analyzed. Patients with AAA were divided into progression (growth rate > 10 mL/year) and non-progression groups, as well as those with NAFLD and without NAFLD, based on abdominal CT results. The Kaplan-Meier and Cox regression were used to investigate the association between NAFLD and AAA progression. Results A total of 151 patients with AAA (mean age: 69.1 ± 10.5 years old, 133 men) were included, among which 66 patients (43.7%) had NAFLD. During a median of 10.7 months (6.0–76.0 months), 57 patients (37.7%) had AAA progression. The prevalence of NAFLD was significantly higher in the AAA group compared to the control group (43.7% vs. 31.1%, p = 0.024). Multivariable regression analysis revealed that the NAFLD was independently associated with AAA progression (HR, 4.28; 95% CI, 2.20–8.31; p
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