Changes of PEPCK Gene Expression in Liver Tissue and HOMA-IR after High-Intensity Interval Training and Royal Jelly Consumption in Rats with Type 2 Diabetes
| Autor: | Mohammad Reza Yeylaghi Ashrafi, Hossein Abednatanzi, Farshad Ghazalian |
|---|---|
| Jazyk: | English<br />Persian |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 31, Iss 196, Pp 111-124 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: Type 2 diabetes is the most common endocrine disease due to glucose intolerance and imbalance between reserves and insulin demand. The aim of this study was to investigate the interactive effect of intensity interval training and n-chromosomal royal jelly on PEPCK gene expression of hepatocytes and glucose levels and insulin resistance in type 2 diabetic rats. Materials and methods: This experimental study was done in 36 Wistar rats (4-6 weeks, 100±20 g). After 20 weeks of high-fat diet, diabetes was induced by intraperitoneal injection of 25 mg STZ per kg body weight. The rats were treated in four groups: control (n=8), training (n=10), royal jelly (n=8), and training-Royal Jelly (n=10). Training protocol continued for eight weeks, including High-intensity interval training (HIIT) for five sessions per week with 2-minute alternation of 2 and 8 interval at 80 to 90% vo2max and a one-minute rest cycle at 50 to 56% vo2max. Results: Compared to the control group, aerobic exercise led to significant reductions in glucose level and insulin resistance (both P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|