The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
| Autor: | Eunjeong Kwon, Kristina Todorova, Jun Wang, Rastislav Horos, Kevin K. Lee, Victor A. Neel, Gian Luca Negri, Poul H. Sorensen, Sam W. Lee, Matthias W. Hentze, Anna Mandinova |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 37590464 |
| DOI: | 10.1038/s41467-018-04092-0 |
| Popis: | The integrity of the stratified epithelia relies on controlled cell turnover but it is unclear how mRNA binding proteins regulates this. Here, the authors show that the RNA binding protein Y-box binding protein-1 translationally represses cytokines, so preventing senescence and maintaining epidermal homeostasis. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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