The influence of dehydration on the prognosis of acute ischemic stroke for patients treated with tissue plasminogen activator

Autor: Fei-Fan Wu, Yen-Chu Hung, Y. H. Tsai, Jen-Tsung Yang, Tsong-Hai Lee, Chia-Wei Liow, Jiann-Der Lee, Chung-Jen Lin, Tsung-I Peng, Leng-Chieh Lin
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: BMC Cardiovascular Disorders, Vol 17, Iss 1, Pp 1-12 (2017)
Druh dokumentu: article
ISSN: 1471-2261
DOI: 10.1186/s12872-017-0590-6
Popis: Abstract Background Many studies have determined that dehydration is an independent predictor of outcome after ischemic stroke (IS); however, none have determined if the use of thrombolytic therapy modifies the negative impact of poor hydration. To inform the stroke registry established at our institution, we conducted a retrospective study to determine if dehydration remains a negative prognostic factor after IS patients treated with tissue plasminogen activator (tPA). Methods Between 2007 and 2012, we recruited 382 subjects; 346 had data available and were divided into 2 groups on the basis of their blood urea nitrogen/creatinine (BUN/Cr) ratio. Dehydrated subjects had a BUN/Cr ratio ≥ 15; hydrated subjects had a BUN/Cr
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