Neuroprotective effects of the fractions of Ocimum basilicum in seizures induced by pentylenetetrazole in mice
| Autor: | Somaieh Mansouri, Mahmoud Hosseini, Fatemeh Alipour, Farimah Beheshti, Hassan Rakhshandeh, Abbas Mohammadipour, Akbar Anaeigoudari, Mohammad Jalili-nik, Mohammad Reza Khazdair, Amirali Jahani |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Avicenna Journal of Phytomedicine, Vol 12, Iss 6, Pp 614-626 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2228-7930 2228-7949 |
| DOI: | 10.22038/ajp.2022.20470 |
| Popis: | Objective: Neuroprotective and antioxidant effects of Ocimum basilicum (O. basilicum) against pentylenetetrazole (PTZ)-induced seizures were investigated. Materials and Methods: Mice were divided as follows: (Group 1) Control, (Group 2) PTZ, (Groups 3-5) 50,100 and 200 mg/kg hydro-ethanolic (HE) extract, and (Groups 6-8) 200 mg/kg ethyl-acetate (EAF), N-hexane (NHF) and water (WF) fractions. Minimal clonic seizures (MCS) and generalized tonic-clonic seizures (GTCS) latencies were measured. Biochemical and histological studies were done.Results: MCS and GTCS latency in HE groups were longer than the PTZ group (p |
| Databáze: | Directory of Open Access Journals |
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