Treatment expectations and clinical outcomes following repetitive transcranial magnetic stimulation for treatment-resistant depression

Autor: Adriano Mollica, Enoch Ng, Matthew J. Burke, Sean M. Nestor, Hyewon Lee, Jennifer S. Rabin, Clement Hamani, Nir Lipsman, Peter Giacobbe
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Brain Stimulation, Vol 17, Iss 4, Pp 752-759 (2024)
Druh dokumentu: article
ISSN: 1935-861X
DOI: 10.1016/j.brs.2024.06.006
Popis: Background: Patient expectations, including both positive (placebo) and negative (nocebo) effects, influence treatment outcomes, yet their impact on acute repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant depression (TRD) is unclear. Methods: In this single-center retrospective chart review, 208 TRD patients completed the Stanford Expectation of Treatment Scale (SETS) before starting open-label rTMS treatment. Patients were offered two excitatory rTMS protocols (deep TMS or intermittent theta-burst stimulation), which stimulated the left dorsolateral prefrontal cortex. A minimum of 20 once daily treatments were provided, delivered over 4–6 weeks. Primary outcomes were 1) remission, measured by a post-treatment score of
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