| Autor: |
Lvpiao Zheng, Ziling Luo, Biswaranjan Mohanty, Sana Amoozegar, Luke A. Johnson, Jerrold L. Vitek, Jing Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-5 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2373-8057 |
| DOI: |
10.1038/s41531-024-00797-w |
| Popis: |
Abstract Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson’s disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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