Expression of nAChRα7 receptor in model rats with Parkinson’s disease dementia

Autor: Yan Pan, Jing Zhu, Lina Cong, Yang Bai, Yaxin Ma, Yue Yang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 117-123 (2021)
Druh dokumentu: article
ISSN: 1310-2818
1314-3530
13102818
DOI: 10.1080/13102818.2020.1829500
Popis: To investigate the expression and role of nicotinic acetylcholine α7 subunit (nAChRα7) in the hippocampus of rats with Parkinson's disease (PD) and Parkinson's disease dementia (PDD). PD model was established with 6-hydroxydopa. Then, methyllycaconitine was further used to prepare a PDD model. The behavioral indexes and malondialdehyde (MDA) and superoxide dismutase (SOD) levels were measured. The mRNA level and protein level of nAChRα7 in hippocampus was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western-blot, respectively. The α7nAchR and NeuN protein was detected by immunofluorescence. Compared with the PD model group, the escape latency of the PDD model group was significantly prolonged while the times of crossing platforms was significantly reduced (p
Databáze: Directory of Open Access Journals
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