Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil
| Autor: | Jefferson José da Silva Santos, Tereza Magalhães, José Valter Joaquim Silva Junior, Andréa Nazaré Monteiro Rangel da Silva, Marli Tenório Cordeiro, Laura Helena Vega Gonzales Gil |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 110, Iss 5, Pp 677-683 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1678-8060 0074-0276 |
| DOI: | 10.1590/0074-02760150053 |
| Popis: | Full-length dengue virus (DENV) cDNA clones are an invaluable tool for many studies, including those on the development of attenuated or chimeric vaccines and on host-virus interactions. Furthermore, the importance of low passage DENV infectious clones should be highlighted, as these may harbour critical and unique strain-specific viral components from field-circulating isolates. The successful construction of a functional Brazilian low passage DENV serotype 2 full-length clone through homologous recombination reported here supports the use of a strategy that has been shown to be highly useful by our group for the development of flavivirus infectious clones and replicons. |
| Databáze: | Directory of Open Access Journals |
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